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Optical trapping single proteins in real time

Experimental optical tweezer set-up

Experimental set-up showing the (a) optical tweezers and (b) camera image of the reflected laser fringe pattern (c) Scanning electron microscope image of a double nanohole (d) Interference pattern changes as the protein moves toward the centre. Scattering from the protein (Es) interferes with the surface plasmon wave (Ep) and the reflected laser (Er) (Image: Matthew Peters, UVic)

Gold films with integrated nanostructures are being used to trap individual proteins and observe the smallest proteins without labelling

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