A research team at the University of Glasgow has created what it calls 'super-twisted light,' for the first time. The team twisted the light like a corkscrew by using a polarising filter, before shining it onto a specially shaped piece of gold. Super-twisted light does not exist in nature and, until now, it had only been theorised by scientists, but never produced. Super-twisted light can be used to find protein traces in incredibly small samples of biological material such as blood, at far lower concentrations than are currently resolvable.
The researchers have already used the light to look at many different proteins and have found that it is particularly sensitive to the structures of proteins which cause degenerative diseases such as Alzheimer’s and Parkinson’s Disease.
Dr Malcolm Kadodwala, senior lecturer in the School of Chemistry, said: 'We are very excited by this research. Essentially, this twisted light allows us to detect biological materials at unprecedented low concentrations. Due to the nature of the twisted light, it has been shown to be particularly effective at detecting proteins with a structure characteristic of amyloids – insoluble proteins that can stick together to form plaques within different organs in the body. It is these plaques which are thought to play a part in neurodegenerative diseases such as Alzheimer’s, Parkinson’s and CJD – though the reasons for this are unclear. We’re now looking to see if this same technique can be adapted to detect a wider range of proteins which are indicative of other diseases. The fact this method requires much less material (just one picogram or million millionth of a gram) for analysis than current techniques and uses a form of light previously unrealised is a big step forward,' he said.
The complex science behind the technique takes advantage of the fact light can be twisted like a corkscrew by passing it through a special polarising filter, in much the same way as polarised sunglasses allow only certain alignments of light waves through. By shining light onto a specially-shaped piece of metal (in this case gold) the light that is emitted from the metal becomes super-twisted. Polarised or twisted light is already used in some medical techniques to analyse biomolecules, however the multidisciplinary Glasgow team, have been able to achieve a much more powerful system by twisting the light even tighter. According to the team, the use of super-twisted light in spectroscopy has numerous potential applications in biosensing, and could also be used to detect particular types of viruses which have similar structures.